Xu LL, Xiang HD, Zhang LH, Chen W, Fang JH
[Changes of insulin resistance and islet beta cells function in subjects with high-normal blood pressure] [English Abstract, Journal Article, Research Support, Non-U.S. Gov't]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2009 Aug; 31(4):494-7.
OBJECTIVE: To investigate the changes of insulin resistance and islet beta cells function in subjects with euglycemia and high-normal blood pressure.
METHODS: Total 423 subjects were divided into normal blood pressure group and high-normal blood pressure group. Body height, weight, waist and hip circumference, and biochemical data were measured. Homeostasis model assessment of insulin resistance (HOMA-IR), insulin sensitivity index (ISI)-composite, and first-phase (1 PH) Stumvoll index were calculated. Results Waist circumference, total cholesterol, triglyceride, low-density lipoprotein cholesterol, HOMA-IR were significantly higher and IPH Stumvoll index and ISI-composite were significantly lower in high-normal blood pressure group than in normal blood pressure group (P < 0.05). Systolic blood pressure (SBP) was positively correlated with HOMA-IR (r = 0.122) and negatively correlated with 1PH Stumvoll index (r = -0. 159) and ISI-composite (r = -0.131) (P < 0.05). SBP and triglyceride were independent factors for IPH Stumvoll index.
CONCLUSION: Insulin resistance and islet dysfunction may exist in subjects with high-normal blood pressure.
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